CORDIS Project
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This project investigates the molecular mechanisms of sperm-egg recognition and fusion in vertebrates, using zebrafish as a model. By combining in vivo and in vitro approaches, it aims to uncover the essential components and principles governing fertilization processes.
The life of every sexually reproducing being can be traced back to a singular event: the fusion of sperm and egg.
Gamete fusion is perhaps the most critical step in the process of fertilization.
However, the mechanisms underlying vertebrate sperm-egg fusion and the events that precede it (sperm-egg recognition) are largely unknown.
Uncovering the molecular machinery and biophysical mechanisms mediating sperm-egg recognition and membrane fusion in vertebrates is therefore one of the biggest chall…
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