CORDIS Project
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This project investigates gamma-secretase allosteric modulators as potential preventative treatments for Alzheimer's Disease. By leveraging a novel animal model, it aims to provide evidence for the safety and efficacy of these compounds in preventing disease pathology.
The recent advent of therapeutic Aβ-antibodies has validated amyloid plaques as drug targets in Alzheimer’s Disease (AD).
They remain expensive, prone to side effects, and clinical benefit is limited.
The field needs a safe and cheap drug, preferably a small compound that can be taken orally, and in a preventative way before brain damage has occurred.
Despite strong theoretical potential, further clinical development of gamma-secretase allosteric modulators (GAM), is currently hampered by the la…
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