CORDIS Project
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This project investigates how galectin-3, a cellular lectin, facilitates the uptake of specific cargo proteins into cells through unique tubular structures. It aims to uncover the mechanisms behind clathrin-independent endocytosis and its role in cell adhesion and migration, particularly in the context of wound healing…
The contribution of clathrin-independent endocytosis to the cellular entry of signaling receptors, cell adhesion factors, and other cell surface molecules is well documented.
However, how this process is initiated is still unknown.
We have recently found that a cellular lectin, galectin-3 (Gal3), entered cells via morphologically distinct tubular structures, so-called clathrin-independent carriers (CLICs);
Gal3 endocytosis was required for the uptake of the CLIC cargo CD44, a cell adhesion/migra…
INSTITUT CURIE
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Australia, Sydney
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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