CORDIS Project
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The project aims to develop non-invasive methods for assessing osteoarthritis in mice by analyzing gait patterns. By correlating these patterns with joint degeneration, the research seeks to improve the understanding and detection of osteoarthritis, potentially accelerating the development of new therapies.
Osteoarthritis (OA) is a painful and disabling, multi-factorial disease with strong genetic and environmental determinants.
The natural form of OA that arises spontaneously in Str/ort mice has been used as a model for human OA joint degeneration.
This model is limited, however, because it is impossible to grade OA incidence and severity non-invasively in mice.
Locomotor biomechanics provides a unique tool for non-invasively assessing knee dynamics, and has already been used to detect gait modifi…
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