CORDIS Project
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This project investigates the role of Neuregulin-1 and its receptor ErbB4 in the development of GABAergic interneurons, which are crucial for brain function. Using various experimental techniques, the research aims to uncover insights into the biological mechanisms underlying schizophrenia.
Schizophrenia is a psychiatric illness affecting nearly 1% of the population that is though to arise as a consequence of abnormal brain development.
Structural deficits are relatively subtle in schizophrenia; however, there is evidence for a reduced volume of the neocortex, probably linked to perturbed development of the neuropil, and significant alterations in GABAergic neurotransmission in patients with schizophrenia.
Recent genetic studies suggest that Neuregulin-1 (Nrg1) and its receptor E…
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
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