CORDIS Project
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This project explores the structural organization of GABA(A) receptors and their associated proteins, which are crucial for inhibitory neurotransmission. By using advanced imaging techniques, it aims to understand the molecular basis of neurodevelopmental disorders linked to dysfunctional receptor clustering.
GABA(A)Rs are the principal neurotransmitter receptors at the inhibitory synapses.
The majority of these receptors are anchored at the inhibitory postsynaptic compartment by the central scaffolding function of gephyrin. A dysfunctional receptor clustering by gephyrin leads to abnormal neurotransmission and neurodevelopmental disorders, including anxiety disorders and epilepsy.
Recent advances in the structural studies, most recently by cryo-electron microscopy (cryo-EM), have elucidated several…
UNITED KINGDOM RESEARCH AND INNOVATION
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