CORDIS Project
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This research project aims to develop computational methods for identifying small molecules that can selectively target G-quadruplex DNA associated with cancer. By creating multi-target quantitative structure-activity relationship models, the project seeks to enhance targeted cancer therapies through the stabilization…
The goal of the proposed research is to develop computational methodology which can screen out small ligand molecules having potential to selectively target G-quadruplex (G4) DNA which are associated with cancer pathology.
Multiple oncogenes and telomerase activity are deregulated in various types of cancers.
Ligand induced stabilization of G4s associated with the oncogenes (c-myc, c-kit, k-ras, etc.) and stabilization of telomeric G4s are efficient ways in targeted cancer therapy.
Here, we inte…
MOLDRUG AI SYSTEMS SL
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