CORDIS Project
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This project investigates the mechanisms by which Kaposi's sarcoma-associated herpesvirus maintains latency, focusing on the role of specific DNA structures called G-quadruplexes. Using an in vitro system derived from frog eggs, the research aims to uncover strategies to disrupt viral persistence, potentially leading t…
Kaposis sarcoma-associated herpesvirus (KSHV) is a widespread oncogenic virus, whose infection can cause Kaposis sarcoma, an incurable cancer frequent in immunocompromised individuals.
Similar to other herpesviruses, KSHV establishes a latent infection in the host, characterized by lifelong persistence of the viral genome.
Necessary and sufficient for latent infection are the virally expressed latency-associated nuclear antigen (LANA) and highly repetitive GC-rich sequences on the viral genome,…
UNIVERSITA DEGLI STUDI DI PADOVA
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