CORDIS Project
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This project investigates RNA-mediated mechanisms of genome regulation in ciliated protozoa, focusing on how RNA guides chromosomal rearrangements. It aims to understand these processes' implications for genome editing in higher eukaryotes, including human cancer cells.
The goal of this project is to contribute to our understanding of RNA-mediated epigenetic mechanisms of genome regulation in eukaryotes.
Ciliated protozoa offer a fantastic opportunity to investigate the complex process of trans-generational programming of chromosomal rearrangements, which is thought to serve as a form of immune defense against invasive DNA.
Developmental processes in ciliates include extensive rearrangements of the germline DNA, including elimination of transposons and the prec…
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