CORDIS Project
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This project investigates the mechanisms of HIV-1 fusion and neutralization by antibodies using advanced microscopy techniques. It aims to provide insights that could inform the design of effective vaccines and therapies against HIV-1 by visualizing interactions at the molecular level.
The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field.
This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy.
The molecular mechanism of time-resolved HIV-1 fusion w…
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