CORDIS Project
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This research aims to understand how a specific RNA helicase, CHAMP, regulates the growth of heart muscle cells by controlling the translation of critical proteins. The study integrates molecular biology and biophysics to explore the mechanisms behind heart development and hypertrophy.
Adult cardiac myocytes retain the ability to respond to a variety of stimuli by hypertrophic growth.
Hypertrophy is initially beneficial, permitting enhanced cardiac output; it can ultimately become deleterious and result in cardiomyopathy, heart failure, and sudden death.
Mitogenic signaling drives cell cycle progression as consequences of their effects on cyclins, which interact with cyclin-dependent kinases and cyclin-dependent kinase inhibitors.
Recent work showed that CHAMP has antihypertro…
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