CORDIS Project
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This project investigates R-bodies, large protein structures in bacteria, focusing on their assembly, mechanism of action, and potential roles in symbiosis or pathogenicity. It aims to understand their biological significance and regulatory mechanisms within bacterial populations.
R-bodies are probably the largest organised intracellular proteinaceous structures in bacteria.
They adopt a roll-like structure that occupies almost the entire cellular volume.
Upon acidification, R-bodies extend telescopically up to 20 micrometres.
First discovered in endosymbiotic bacteria, they were proposed to eliminate symbiont-free hosts, however their mechanism of toxicity remained unexplored.
In addition, structures of similar composition and activity form ejectile defence organelles in…
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