CORDIS Project
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This project investigates the use of low intensity focused ultrasound combined with microbubbles to enhance the clearance of pathological proteins in the brain, aiming to prevent cognitive decline in Parkinson's Disease Dementia. It focuses on understanding microglial function and synapse health.
Over half of Parkinson Disease patients develop cortical dysfunctions leading to Parkinson Disease Dementia (PDD).
The cognitive changes are primarily driven by pathological alpha-synuclein (a-syn) protein aggregates with secondary synaptic dysfunctions in the cortex.
Microglia plays a key role in synapse maintenance and clearance of aggregated a-syn proteins, however, this is impaired in PD.
Low intensity focused ultrasound (FUS) combined with intravenous microbubbles (MB) can non-invasively in…
AARHUS UNIVERSITET
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