CORDIS Project
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This project investigates the mechanisms controlling mitochondrial movement within neurons, crucial for energy supply and calcium regulation. By examining how specific proteins influence mitochondrial trafficking, it seeks to enhance understanding of neuronal development and function, with implications for neurological…
Regulated trafficking of mitochondria is essential for providing ATP at the correct spatial location to power neural computation, and for providing calcium buffering at sites of calcium entry or release.
In neurons, the concentration of mitochondria in specific regions such as growth cones and synapses is important for correct neuronal function and development.
Moreover mutations in proteins regulating mitochondrial trafficking compromise neuronal development and the formation, function and plas…
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