CORDIS Project
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The project investigates the transport of brain-derived neurotrophic factor (BDNF) in neurons, focusing on the role of the huntingtin protein in energy regulation during this process. It aims to understand how mutations in huntingtin affect BDNF transport and explore potential therapeutic strategies for Huntington's di…
Fast axonal transport (FAT) of brain-derived neurotrophic factor (BDNF) is essential for brain function.
It depends on huntingtin (HTT), the protein that when mutated causes Huntington’s disease (HD), a devastating and still incurable disorder.
Unmet scientific needs:
BDNF is regulated by neuronal activity and its transport requires energy.
Yet we do not know if FAT of BDNF is regulated by neuronal activity and if HTT facilitates activity-dependent transport.
The energy sources for FAT of BDNF a…
UNIVERSITE GRENOBLE ALPES
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