CORDIS Project
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The project aims to create cerebral organoid models of frontotemporal dementia to study disease mechanisms and potential therapies. It will analyze protein aggregation and cellular responses in these models to better understand the pathology of this neurodegenerative disease.
Frontotemporal dementia (FTD) is the second most common form of dementia. A pathological hallmark is the formation of protein aggregates that consist mainly of Tau or TDP43.
Patients suffer from the degeneration of the frontal and temporal lobes with no effective treatments being available.
The recent advancement of 3D brain organoid cultures grown from embryonic stem cells offer new possibilities to study disease mechanisms of neurological disorders and help validate therapeutic interventions.…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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