CORDIS Project
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This project investigates the evolutionary origins of Bacillus anthracis, the anthrax pathogen, by studying its relationship with insect pathogens. It aims to understand gene regulation and virulence in related strains using various infection models.
Despite their importance, little is known about the origins of many emerging human pathogens and the way that invertebrates could shaped their evolution.
Bacillus anthracis, the causative agent of anthrax, is closely related to the important insect associated pathogens B. cereus and B. thuringiensis.
In B. anthracis, it has been proposed that the horizontal acquisition of the mammalian virulence regulon atxA created a dynamic tension with the insect virulence regulon plcR, which resulted in the…
UNIVERSITY OF BATH
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