CORDIS Project
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This project focuses on developing novel fluorescent molecular rotors to measure the microviscosity of cellular environments through fluorescence lifetime. These advanced dyes aim to enhance imaging techniques in biological research, particularly during cancer treatments like Photodynamic Therapy.
This project proposes to design and synthesise a series of novel fluorescent molecular rotors able to measure microviscosity of cellular domains based on the fluorescence lifetime.
The fluorescence detection is an efficient and direct way to localise the molecules within cells whereas the measurement of the fluorescence lifetime provides a number of additional assets since the fluorescence decay is typically sensitive to the environment of the fluorophore.
In molecular rotors the lifetime can be…
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