CORDIS Project
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This project investigates the molecular mechanisms that govern the development of hematopoietic stem cells (HSCs) during embryonic life. It focuses on the role of Fringe-glycosyltransferases in modulating Notch signaling, which is crucial for HSC emergence and differentiation.
Hematopoietic Stem Cell (HSC)-based therapies are becoming a great expectation for the cure of several disorders that require HSCs for treatment.
However, the incapacity to generate and maintain fully potent transplantable HSCs in vitro is still nowadays one of the main limitations for their wide application in cellular therapies.
The study of the molecular mechanisms underlying HSC ontogeny in embryos is thus of crucial importance in order to elucidate the genetic networks that control the emer…
FUNDACIO INSTITUT HOSPITAL DEL MAR D INVESTIGACIONS MEDIQUES
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