CORDIS Project
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This project aims to develop a high-throughput assay to identify hypersensitive platelets that can drive blood clotting. By using microfluidic platforms, it seeks to isolate and analyze single platelets during activation, providing insights into their dynamics and potential therapeutic applications for high-risk groups…
Single activated platelets can activate other platelets to drive blood clotting.
Single, hyper-sensitive platelets could coordinate clotting in healthy individuals or cause pathological clotting in high risk groups such as the elderly, obese peoples and smokers.
To identify potentially rare hypersensitive platelets, an assay must enable high throughput population profiling with all platelets isolated to avoid cross-talk.
Platelet activation is associated with a <5 second transformation from a di…
UNIVERSITY OF SOUTHAMPTON
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