CORDIS Project
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This project investigates how microglia, the brain's immune cells, respond to dying neurons. By using zebrafish embryos and advanced imaging techniques, it aims to uncover the mechanisms that guide microglial movement towards damaged neurons, enhancing our understanding of brain health and disease.
A significant proportion of neurons in the brain undergo programmed cell death.
In order to prevent the diffusion of damaging degradation products, dying neurons are quickly collected by microglia, specialised phagocytes that are resident in the brain.
Despite the importance of these cells in several neuronal pathologies, many fundamental questions concerning microglial-neuronal interactions remain unaddressed.
How these cells collectively ensure that the entire brain is surveyed and how they re…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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