CORDIS Project
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This project investigates how the dysregulation of FOXO transcription factors contributes to increased transcriptional noise in endothelial cells, which may lead to vascular dysfunction and age-related diseases. By understanding these mechanisms, the research aims to identify potential interventions to maintain vascula…
Ageing is the result of accumulated cellular dysfunction and loss of tissue homeostasis, which often leads to the emergence of age-related pathologies such as cancer and cardiovascular disorders.
The disruption of tissue homeostasis during ageing is particularly critical in the case of the vascular endothelium.
The signaling interface and barrier to external factors is provided by a single layer of endothelial cells in a quiescent state.
The maintenance of this quiescent state plays an important…
NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT
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