CORDIS Project
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This research focuses on identifying the functions of uncharacterized proteins from fungi, aiming to develop a pipeline for discovering new biocatalysts. By exploring biosynthetic enzymes, it seeks to enhance biotechnological applications through enzyme characterization and genome mining.
Fast advances in genome sequencing and sequence processing technology leave ~30% of predicted proteins as orphans, meaning without known function or closely related enzymes.
Being able to assign a function to such orphans opens avenues to select for and design powerful biocatalysts – individual enzymes, biosynthetic pathways or entire organisms.
The herein proposed research aims at developing a de-orphanizing pipeline “fORPHAN” based on computational and experimental characterization of enzymes…
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