CORDIS Project
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This project investigates how non-alcoholic fatty liver disease (NAFLD) affects liver cell interactions and memory, potentially leading to persistent inflammation and increased susceptibility to liver damage even after weight loss. By using advanced sequencing techniques, it aims to uncover the underlying mechanisms an…
With the obesity epidemic, global prevalence of non-alcoholic fatty liver disease (NAFLD) is currently at 25% and rising. NAFLD results from accumulation of excessive fat in the liver and covers a spectrum of disease states from simple steatosis (fatty liver) to severe non-alcoholic steatohepatitis (NASH). NAFLD patients are also at increased risk of developing secondary pathologies, including infections and paracetamol-induced liver damage, although the mechanisms behind this remain unclear.
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