CORDIS Project
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This project investigates the role of folate receptor 2-expressing macrophages in breast tumors and their influence on CD8+ T cell responses. By understanding how these macrophages contribute to the formation of tertiary lymphoid structures, the research aims to enhance immunotherapy strategies against cancer.
The infiltration of CD8+ T cells in tumors is crucial for the development of immunity against cancer.
We have recently identified a tissue-resident macrophage population expressing the folate receptor 2 (FOLR2) and infiltrating human and murine breast tumors.
We have shown that tumor-infiltrating CD8+ T cell form lymphoid aggregate around FOLR2+ macrophages in a perivascular niche.
The abundance of FOLR2+ macrophages associates with lymphocyte infiltration, the onset of tertiary lymphoid structu…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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