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The FOLOF project focuses on developing synthetic molecules called aromatic oligoamide foldamers to mimic the structure of DNA. By enhancing the design and synthesis of these molecules, the project aims to improve the control of protein-nucleic acid interactions for potential therapeutic applications.
Protein-nucleic acid interactions (PNIs) play a central role in biology and their control would enable long-desired biological interventions and future therapeutic applications.
However, synthetic molecules that reproduce the overall shape and surface features of nucleic acids to interfere with PNIs have been lacking because, up to now, it has not been possible to design such extended and complex abiotic interactions interfaces.
Due to their distinct chemical composition, predictable shapes, lar…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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