CORDIS Project
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This project investigates the progression of follicular lymphoma, focusing on how specific immunoglobulin classes influence the transformation from early lesions to aggressive forms of the disease. Using advanced genomic techniques, it aims to uncover the roles of these immunoglobulins in tumor development and patient…
Follicular lymphoma (FL) is the second most common B cell neoplasm, characterized by the t(14;18) chromosomal translocation, resulting in deregulated BCL2 oncoprotein (BCL2tx+).
In situ follicular neoplasia (ISFN) represents an early precursor lesion, histologically identified as BCL2+/CD10+ Germinal Centers (GC), that might progress into FL.
Spatial and temporal genomic analysis in FL revealed that its transformation into aggressive high-grade MYC/BCL2 Double-Hit lymphoma (DHL) arises predomina…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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