CORDIS Project
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This project investigates the role of Polycomb group and trithorax group genes in gene regulation, focusing on their mechanisms of action in maintaining gene expression states. It employs various biological and computational techniques to understand their impact on development, cell proliferation, and cancer across dif…
Polycomb group (PcG) and trithorax group (trxG) genes were discovered in Drosophila melanogaster as repressors and activators of Hox genes, a set of transcription factors that specify the antero-posterior axis of the body plan.
PcG and trxG proteins form multimeric complexes that are required to maintain their expression state after the initial transcriptional regulators disappear from the embryo.
Subsequent work led to a better understanding of their mechanisms of action.
Moreover, PcG and trxG…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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