CORDIS Project
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This project investigates the role of intestinal stem cells in maintaining gut health using fruit flies as a model. It aims to identify signals that regulate stem cell activity and their communication with other organs, potentially revealing insights applicable to mammalian health and disease.
Due to its remarkable self-renewing capacity, the fly gut has recently become a prime paradigm for studying stem-cell function during adult tissue homeostasis.
This capacity for self-renewal relays on the proliferative activity of the intestinal stem cells (ISC), which is tightly coupled with cell loss to maintain intestinal homeostasis. ISC proliferation is controlled by multiple local and systemic signals released from the ISC niche (enterocytes (ECs), enteroendocrine (EE) cells, enteroblasts…
KOBENHAVNS UNIVERSITET
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