CORDIS Project
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This project explores how fluid shear stress influences electrolyte balance in the kidneys. It focuses on the role of polycystin-1 in signaling pathways that regulate ion transport, aiming to enhance understanding of kidney function.
The principal role of the kidneys is the critical regulation of our electrolyte balance, through an integrated system of reabsorption and secretion of fluid and electrolytes.
Once blood is filtered in the glomeruli, renal electrolyte reabsorption rate has to be adjusted to the variable electrolyte load associated with fluctuations of the pro-urine flow.
The variable flow of pro-urine results in changing fluid-shear stress (FSS) that activates mechanosensitive signalling pathways in the epithelia…
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