CORDIS Project
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The project aims to explore the genetic factors that contribute to the virulence of Salmonella Typhi, a significant human pathogen. Using CRISPR technology, it will create a library of mutant strains to study their interactions with host cells and understand the dynamics of infection.
Over the course of host-pathogen evolution, both the players in this game have set out strategies to overcome each other, by adapting to challenging environments and camouflaging on the one side, and by detecting and eradicating the enemy on the other.
In this context, the identification of the pathogenic potential, that is, the genetic elements conferring virulence and how they subvert the host’s defences, is fundamental.
With a multiplexed approach, I aim at developing a pooled genetic screen…
WEIZMANN INSTITUTE OF SCIENCE
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