CORDIS Project
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This project explores pain responses in zebrafish, comparing larval and adult forms to enhance understanding of nociception. By analyzing behavior and gene expression, it aims to develop a reliable protocol for testing analgesic drugs, ultimately improving welfare in research settings.
The zebrafish (ZF) is now a widely accepted vertebrate model for research in genetics, neuroscience and development due to its sheer experimental convenience and also its gene, developmental and functional homologies with mammals. ZF are also exploited as a novel model in nociceptive or pain research in a number of laboratories.
We are already assessing behavioural and physiological responses in adult ZF to pain but wish to also explore whether embryonic and larval forms offer a useful alternati…
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