CORDIS Project
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This project investigates the role of maternal genetics and health in the development of congenital heart defects in infants. By analyzing extensive health data and biological samples, it aims to uncover how maternal factors contribute to the risk of these defects, potentially leading to improved understanding and prev…
One in a hundred infants is born with a congenital heart defect (CHD).
Both genetic and environmental risk factors, such as maternal diabetes and obesity, are known to cause CHD, however, little is known about the disease mechanisms behind these risks. CHD can occur as an element of a syndrome, in conjunction with other anomalies, or as an isolated defect. I propose that there is an etiologically distinct environmental CHD subgroup, where in addition to the childs genes, maternal genetics and ge…
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