CORDIS Project
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The FimH-Mech project investigates how specific proteins in E. coli bacteria contribute to their ability to adhere to host cells, influencing pathogenicity. By studying the molecular mechanisms of these proteins under different conditions, the project aims to develop new non-antibiotic treatments against harmful bacter…
Pathogenic bacteria such as E. coli are responsible for a large variety of diseases, including persistent urinary tract and intestinal infections.
Their adhesion to the host cell wall is promoted by the binding of FimH located at the tip of the bacterial fimbriae to highly mannosylated cell surface receptors.
To resist human defences such as the urinary flow, bacterial adhesion is enhanced under shear force.
The shear-force dependence and thus also the pathogenicity of different E. coli strains…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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