CORDIS Project
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This project investigates the role of Fic proteins in bacterial infections, focusing on their ability to modify host proteins through post-translational modifications. By understanding these mechanisms, the research aims to reveal how pathogens manipulate host cellular processes for persistent infections.
The ubiquitous FIC domain catalyzes post-translational modifications (PTMs) of target proteins; i.e.adenylylation (=AMPylation) and, more rarely, uridylylation and phosphocholination.
Fic proteins arethought to play critical roles in intrinsic signaling processes of prokaryotes and eukaryotes; however, asubset encoded by bacterial pathogens is translocated via dedicated secretion systems into the cytoplasm ofmammalian host cells.
Some of these host-targeted Fic proteins modify small GTPases lead…
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