CORDIS Project
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FIBROLEAD focuses on developing VM-313, a compound targeting fibroblasts to address chronic inflammation and fibrosis in inflammatory bowel disease (IBD). By improving treatment strategies, it aims to enhance patient outcomes and reduce disease progression.
Inflammatory bowel disease (IBD), which comprises Crohn's disease (CD) and ulcerative colitis (UC), is a growing global health challenge affecting over 6.8 million people.
Characterized by chronic inflammation leading to intestinal fibrosis, IBD significantly reduces quality of life and increases the risk of severe complications, including colon cancer.
Current treatments primarily target inflammation, and fail to address the persistent activation of inflammatory fibroblast phenotypes and the re…
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