CORDIS Project
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The project investigates the role of fibroblastic reticular cells in lymph nodes and their impact on T cell responses to tumors. It aims to understand how these cells may inhibit anti-tumor immunity, providing insights for developing effective cancer immunotherapies.
Lymph nodes are sites where immune responses are robustly initiated.
Paradoxically, they are also very common metastatic sites, where tumour progression is well-tolerated.
Robust evidence defines a role for fibroblastic reticular cells (FRCs) in preventing T cells from acquiring effector functions within lymph nodes, and deleting T cells that show self-reactivity. FIBROCAN will test the hypothesis that FRCs systematically shut down anti-tumour T cell responses, testing mechanisms of suppression…
THE UNIVERSITY OF BIRMINGHAM
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