CORDIS Project
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This project investigates the impact of chemotherapy and radiotherapy on fibroblasts in rectal cancer patients. It aims to understand how these treatments influence tumor relapse and metastasis through a multidisciplinary approach.
Although the therapeutic strategies adopted in the last years for the clinical management of patients with rectal cancer have improved patient’s quality of life, tumor relapse still constitutes to be a factor that determines patient survival.
These patients, usually treated with chemo-radiotherapy (CRT), often develop a CRT-induced fibrosis, which is characterized by an overgrowth of fibroblasts at tumor-treated areas.
The importance of tumor stroma for the development, progression and invasion…
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