CORDIS Project
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This project explores the role of the FIS1 protein in regulating mitochondrial functions and its implications for acute myeloid leukemia. By developing innovative sensors and small molecule inhibitors, the research aims to uncover how FIS1 contributes to the maintenance of leukemia stem cells and potentially lead to ne…
Mitochondrial morphology is controlled by a set of “mitochondria-shaping” proteins that govern fusion and fission of the organelle.
Fission is executed by dynamin-related protein 1 (DRP1) that binds to adaptors on the outer mitochondrial membrane to oligomerize and sever mitochondria.
Fission 1 (FIS1) is among the putative mammalian DRP1 adaptors, but it appears dispensable for mitochondrial fission.
Conversely, FIS1 seems to participate in the regulation of mitochondrial autophagy (mitophagy),…
UNIVERSITA DEGLI STUDI DI PADOVA
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