CORDIS Project
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This project investigates the role of Fibroblast Growth Factor 1 in the development of Type 2 diabetes and obesity. It aims to explore how this factor interacts with the nuclear hormone receptor PPARγ, potentially leading to new therapeutic strategies that minimize side effects associated with current diabetes medicati…
Type 2 diabetes (T2D) and obesity are leading causes of mortality and are associated with the Western lifestyle, which is characterized by excessive nutritional intake and lack of exercise.
A central player in the pathophysiology of these diseases is the nuclear hormone receptor (NHR) PPARγ, a lipid sensor and master regulator of adipogenesis.
PPARγ is also the molecular target for the Thiazolidinedione (TZD)-class of insulin sensitizers, which command a large share of the current oral anti-diab…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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