CORDIS Project
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The project investigates iron-sulfur cluster biosynthesis in human cells, focusing on identifying the associated proteins, understanding regulatory mechanisms, and exploring the interactions of these clusters with cellular functions. This research aims to enhance knowledge of how these clusters support cellular health…
Iron-sulfur (Fe-S) clusters were ancient partners in the origin of life- spontaneously formed in the anaerobic primordial oceans, they likely helped catalyze carbon fixation and rudimentary metabolism.
Highly versatile, Fe-S clusters unlock previously inaccessible abilities for their binding proteins, aiding in electron relay, catalysis, regulation, and structural stability.
Over the past 20 years, it has become clear that Fe-S clusters must be formed de-novo within the cell by essential protein…
WEIZMANN INSTITUTE OF SCIENCE
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