CORDIS Project
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This project investigates the mechanisms behind the high female predominance in pulmonary hypertension, focusing on the role of sex hormones and genetic factors. It aims to identify new therapeutic targets and develop a targeted drug delivery method to improve treatment outcomes for both male and female patients.
Pulmonary hypertension (PH) is a rare but progressive fatal disease characterized by accumulation of persistently activated cell types in the pulmonary vascular wall exhibiting abnormal expression of genes driving proliferation, inflammation, and metabolism.
The currently used vasodilatory therapies have little or no impact on this activated phenotype and therefore offer no cure or even substantial survival benefit. PH has a high female predominance (3:1 to 9:1).
This proposal aims to understand…
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