CORDIS Project
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This project explores the mechanisms of leptin resistance in obesity by studying the interactions between orphan G protein-coupled receptors and leptin receptors in the hypothalamus. It aims to understand how these signaling pathways affect feeding behavior and energy balance, potentially leading to new therapeutic str…
Obesity is a major burden to public health as it increases the risk of several chronic diseases, like diabetes, cardiovascular diseases, musculoskeletal disorders or some cancers.
Energy homeostasis is centrally regulated by the hypothalamus where the arcuate nucleus (ARC) orchestrates feeding behaviors and energy balance.
Two neuronal populations of the ARC are considered as the first-order neurons mediating the effects of various signals such as leptin and insulin, the orexigenic neuropeptide…
UNIVERSITE DE LIEGE
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