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FateMapB explores how fetal hematopoietic stem cells contribute to the adult immune system. By tracing cell lineages, the project aims to clarify the roles of these cells in immune development and their potential for regenerative therapies.
FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells(HSPCs) contribute to functionally distinct cell types of the adult immune system.
While most immune cells are replenishedby HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ.
Thelineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisinglyunclear. I previously…
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