CORDIS Project
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This project aims to develop innovative methods for analyzing gene regulation during early mouse development. By measuring various cellular outputs in single cells over time, it seeks to understand the mechanisms of cell fate specification and the epigenetic states that influence it.
The establishment of cell type-specific transcriptional programs involves many interconnected regulatory mechanisms acting on different genomic scales.
To dissect this multi-layered control of gene expression in detail, I will develop methods that a) measure multiple cellular outputs in single cells, and b) obtain that information in a time-resolved manner.
This proposal outlines my approach to study early mouse development at numerous levels, including (but not limited to) transcription, chroma…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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