CORDIS Project
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This project focuses on developing a method to promote the nuclear localization of FANCA missense mutants in patients with Fanconi anemia. By reactivating the FA/BRCA pathway, the project aims to enhance treatment options for this genetic disorder, potentially leading to personalized therapies for affected individuals.
Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure, malformations and cancer predisposition.
Currently, there is no cure for FA and life expectancy is 29 years.
In addition, FA cells are hypersensitive to DNA coss-linking agents used in chemotherapy making cancer treatment difficult.
The genetic cause of FA is heterogeneous, involving at least 19 different FA genes (FANCA, B, C, D1/BRCA2, D2, E, F, G, I, J, L, M, N, O, P, Q, R, S/BRCA1 and T) all interacting in a commo…
UNIVERSITAT AUTONOMA DE BARCELONA
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