CORDIS Project
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The project focuses on understanding the FOF1-ATPase, a crucial enzyme in cellular energy production. It aims to provide a comprehensive description of its thermodynamic cycle, including the interactions between its catalytic sites, which is essential for advancing knowledge in bioenergetics.
The FOF1-ATPase is a complex nanomotor that synthesizes nearly 90% of the ATP made during cellular respiration.
It consists of two coupled rotary motors: an integral membrane complex driven by proton flow across lipid bilayers (FO) and an enzymatic complex that converts ADP and inorganic phosphate to ATP (F1).
The rotational portion of these motors acts as a camshaft, inducing conformational changes that lead to ATP synthesis in the F1 motor’s three functional catalytic sites.
The F1 motor can p…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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