CORDIS Project
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This project investigates how mechanical stress affects the molecular structure of the extracellular matrix in animal tissues like bone and skin. By developing solid-state nuclear magnetic resonance techniques, it aims to uncover how cells interpret mechanical history and its implications for tissue repair, aging, and…
The mechanical properties of structural animal tissues like bone, tendon and skin are determined by the extracellular matrix (ECM) of the tissue, a complex, changeable 3D material that forms a scaffold around the tissue’s cells.
The matrix is under constant mechanical stress from our everyday movements.
When it is damaged, cells in the tissue repair it; where there is repeated damage, cells must strengthen the matrix, not just repair.
Thus, drivers of cell behaviour are encoded into the detail…
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