CORDIS Project
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This project investigates the role of Transcription Factor IIIC in gene regulation and its interactions with chromatin. By using advanced imaging techniques, it aims to clarify how this factor influences transcription processes and its implications in diseases like cancer.
Gene expression is regulated at many levels since changes in the expression pattern of certain genes might lead to the development of diseases such as cancer.
Transcription is one of these regulation steps, orchestrated by transcription factors and RNA polymerases.
Of these, RNA polymerase III (RNA Pol III) is responsible for transcribing small un-translated RNA molecules, such as tRNA.
Transcription Factor (TF) IIIC (TFIIIC) binds to type 2 promoters (consisting of two conserved boxes, A and B)…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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