CORDIS Project
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This project investigates how embryonic stem cells maintain their ability to self-renew and differentiate by exploring chromatin plasticity. It employs innovative techniques to identify specific chromatin proteins and their roles in stem cell function, aiming to enhance the clinical application of these cells.
How embryonic stem cells (ESCs) maintain their dual capacity to self-renew and to differentiate into all cell types is one of the fundamental questions in biology.
Although this question remains largely open, there is growing evidence suggesting that chromatin plasticity is a fundamental hallmark of ESCs, providing their necessary flexibility.Previously we found that ESCs possess a relatively open chromatin conformation, giving rise to permissive transcriptional program.
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